Erdheim-Chester disease on 18F-FDG PET/CT:A case report

Authors

  • Li Zhou Mianyang Central HospitalDepartment of Nuclear Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China
  • Liming Xiao Department of Nuclear Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China
  • Ziyi Zhao Department of Nuclear Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China
  • Yixiao He Department of Pathology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China,
  • Chunyan Wu Department of Nuclear Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China,
  • Chuandong He Department of Nuclear Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China

DOI:

https://doi.org/10.3941/jrcr.5771

Abstract

Erdheim-Chester disease (ECD) is a rare form of systemic non-Langerhans cell histiocytosis with characteristic bone involvement. Extraskeletal involvement sites were found in central nervous system (CNS), cardiovascular system, lungs, kidneys, and so on. The most common site of CNS involvement is the hypothalamic-pituitary axis, but here we report a rare case of ECD with the frontal lobe involvement.

Then biopsy was then taken from right femur. Histological examination revealed fibrous tissue hyperplasia and foamy histiocytes distributed in nests between bone trabeculae (A, HE × 40; B, HE × 200). Immunohistochemistry (C-D) demonstrated CD68 (+), CD1a (?). P-CK (?), MP0 (scattered and focal +), CD21 (?), CD23 (?), Langerin (?), Ki-67 (+, approximately 3%).

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Published

2025-10-31

Issue

Vol. 19 No. 10 (2025)

Section

Nuclear Medicine / Molecular Imaging

License

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