An Eosinophilic Pneumonia Mimicking Lung Cancer on Multiple Imaging Modalities Monitored By CT

Authors

  • Filippo Montella Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples
  • Ghassan Merkabaoui Medical Oncology Unit, University of Naples Federico II, Naples
  • Antonietta Vitale Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples
  • Guido Faggian
  • Serena De Luca Department of Radiology, PO Maddaloni-San Felice a Cancello, Caserta

DOI:

https://doi.org/10.3941/jrcr.5896

Abstract

Eosinophilic pneumonia (EP) is a rare interstitial lung disease often mimicking other pulmonary conditions. We present the case of a 43-year-old male evaluated for suspected lung cancer due to progressive dyspnea, weight loss, cough. Cytological analysis confirmed an interstitial pulmonary inflammatory process with significant eosinophilic granulocyte infiltration, with no evidence of malignancy. Complete clinical and radiological resolution was achieved within two weeks following corticosteroid and empiric antibiotic therapy. This case highlights the challenging differential diagnosis of EP, especially when mimicking malignancy, emphasizing the crucial role of a complete clinical evaluation based on a multimodality imaging diagnostic assessment and prompt response to corticosteroids for diagnosis confirmation.

(4a-f) Axial (4a,4d), coronal(4b,4e) and sagittal (4c,4f) thin-section contrast-enhanced CT scan in portal venous phase (4a-4c: mediastinal windowing and lung windowing) shows a parenchymal consolidation measuring 38x44x48 mm in the superior lingular segment of the left upper lobe. This lesion is characterized by irregular margins with strands extending to the hilar region and adjacent pleural plane, it also demonstrates inhomogeneous density due to the presence of colliquative areas.

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Published

2025-11-30

Issue

Section

Thoracic Radiology