The Radiologic and Pathologic Diagnosis of Biphasic Pulmonary Blastoma

The Radiologic and Pathologic Diagnosis of Biphasic Pulmonary Blastoma

Fadi Nemeh, Anderson Kuo, Jenny Ross, Carlos S Restrepo


Pulmonary blastomas are rare malignancies, representing 0.25% to 0.5% of all primary lung neoplasms with often aggressive progression and poor prognosis. Clinical management of pulmonary blastomas depends on histologic subtype, staging, and presentation, and may consist of surgery, chemotherapy, and radiation. Biphasic pulmonary blastoma is a subtype of pulmonary blastoma that exhibits biphasic histology, with both epithelial and mesenchymal malignant elements.  We report a case of biphasic pulmonary blastoma in a 33-year-old female with 1 pack per day history of smoking for approximately 16 years, who presented with left-sided pleuritic chest pain on deep inspiration without otherwise significant pat medical history. Imaging evaluation using chest radiography, computed tomography, and magnetic resonance imaging identified a heterogenous, well-circumscribed, left lower lobe mass with extensive necrosis and hemorrhage. No lymphadenopathy or distant metastasis was detected through imaging evaluation. Surgical resection of the tumor followed by histopathological analysis confirmed a biphasic pulmonary blastoma.


Pulmonary Blastoma; Biphasic Pulmonary Blastoma; Pulmonary Neoplasm; Magnetic Resonance Imaging; Computed Tomography