Journal of Radiology Case Reports, Vol 10, No 10 (2016)

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Cerebral Misery Perfusion on Susceptibility Weighted Imaging in Acute Carotid Dissection

Cerebral Misery Perfusion on Susceptibility Weighted Imaging in Acute Carotid Dissection

Arian Mashhood, Geoffrey McWilliams, Paggie Kim, Frankis Almaguel, J. Paul Jacobson

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Abstract


The cerebral vasculature incorporates several fail-safes that must be breached before an irreversible ischemic event takes place. In particular, when autoregulatory vasodilatation fails secondary to falling cerebral perfusion pressure (CPP; stage I hemodynamic failure), increases in the oxygen extraction fraction work to maintain the cerebral metabolic rate of oxygen. Previously, failure of this mechanism, stage II hemodynamic failure, or misery perfusion, has been imaged via positron emission tomography/computed tomography (PET/CT). Current susceptibility-weighted sequences (SWI) allow for more efficient imaging of this physiology. In this case, we identify an incident of reversible ischemia caused by spontaneous carotid artery dissection using a combination of diffusion weighted imaging (DWI) and SWI. The level of hemodynamic failure identified by the imaging sequences elevated the urgency of neurointervention, expediting the patient's arrival to the neurointerventional table and thus avoiding impending irreversible ischemia.

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