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Diffuse pancreatic enlargement is a rare presentation of pancreatic neuroendocrine tumors. In the case of diffuse enlarged pancreas without typical features of acute pancreatitis, autoimmune pancreatitis or lymphoma, diffuse pancreatic neuroendocrine tumor should be considered in a differential diagnosis. Therefore, in these patients performing nuclear medicine imaging, including SPECT and PET, can be helpful before invasive procedure.






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Pancreatic Neuroendocrine Tumor presenting as a diffuse pancreatic enlargement, case report and review of literature

Free full text article: Pancreatic Neuroendocrine Tumor presenting as a diffuse pancreatic enlargement, case report and review of literature

Abstract
Pancreatic neuroendocrine tumors are rare neoplasms that comprise 1-2% of all pancreatic tumors. However, they are the second most common solid pancreatic neoplasms. They have a wide range of imaging appearances and they can show common to very rare imaging presentations. Most of the time they are solitary well-marginated enhancing solid mass arising in a certain aspect of the pancreas. We present a case report of a 41-year-old female who underwent clinical work-up for abdominal pain, loss of appetite and weight loss for the past year. Ultrasound, computed tomography, and magnetic resonance imaging show diffuse homogenous pancreatic enlargement without contour deformity or a focal mass. Lymphoma and autoimmune pancreatitis were suggested based on imaging findings but IGg4 level and other lab data were normal. Endoscopic ultrasonography confirmed the diffuse enlargement of the pancreas without peripheral structures involvement. The pathological results of multiple fine-needle aspiration biopsy from all parts of the enlarged pancreas revealed a low-grade neuroendocrine tumor.






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