Question:

Which of the following is true about Castleman`s Disease?
1. Castlesman`s Disease is a haematogenous disorder.
2. It is classified into unicentric and multicentric diseases.
3. It affects only younger age groups.
4. It occurs only in HIV +ve cases.
5. It occurs only in females





Answer:

The correct answer for the question "Which of the following is true about Castleman`s Disease?" is:

2. It is classified into unicentric and multicentric diseases.



Explanation
1. Castleman`s Disease is a rare lymphoproliferative illness that affects lymph nodes and other immune-cell structures of body.

2. Castleman`s Disease can be classified as a) unicentric vs. multicentric, based on clinical and radiological findings.

3. The average age of people with unicentric castleman`s Disease is around 30 or 40.

4. Castleman`s Disease can be classified as HIV negative versus HIV positive based on the HIV status of the patient.

5. There is no sex predilection for the disease.



From the manuscript:
Unicentric Castleman`s Disease of Abdomen
Radiology Case. 2013 Mar; 7(3):26-33


This article belongs to the GI section.




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From the manuscript

Unicentric Castleman`s Disease of Abdomen

Free full text article: Unicentric Castleman`s Disease of Abdomen

Abstract
Castleman`s disease (CD) is a rare lymphoproliferative disease of uncertain etiology that affects lymph nodes. CD can be classified as a) unicentric vs. multicentric, based on clinical and radiological findings, b) hyaline vascular ( 80-90% ) vs. plasmacytic ( 10-20% ) vs. mixed cellularity variety based on histopathology. Unicentric disease is more common in the 3rd and 4th decade, whereas the multicentric form is more common in the 5th and 6th decade with no sex predilection. HIV seropositive individuals appear to be at an increased risk for multicentric castleman`s disease (MCD) at a younger age due to the increased incidence of HHV- 8 infection. Diagnosis is usually based on histopathology features as imaging features show considerable overlap, thus posing diagnostic difficulties. Overall prognosis is good, particularly in the unicentric variety of disease. We have presented a case of the unicentric CD in a 40 year old male patient having abdominal pain and hematuria as chief complaints.






References



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