Journal of Radiology Case Reports, Vol 13, No 3 (2019)

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Unicentric or Multicentric Castleman disease? A case report of a pelvic intraperitoneal mass in a middle aged woman

Unicentric or Multicentric Castleman disease? A case report of a pelvic intraperitoneal mass in a middle aged woman

Antonella Smedile, Francesca Capuano, Sara Fraticelli, Marco Lucioni, Alfredo La Fianza

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Abstract


Castleman Disease is a lymphoid disorder characterized by the presence of an enlarged or abnormal lymph node/lymphatic tissue. The disease is classified into unicentric or multicentric variants. The unicentric form is a benign disorder that is usually asymptomatic and consists of a single lymphoid mass that is predominantly located in the mediastinum, but can also rarely develop in the neck or abdomen. The multicentric type involves more than one lymphatic station and is related to the presence of type B symptoms (fevers, night sweats and weight loss), HIV/HHV8 infection and increased serum IL-6 levels. We present the case of an unusual pelvic intraperitoneal manifestation of Castleman Disease in a 52-year-old caucasian woman who showed clinical, radiological, histological and laboratory findings common to both Unicentric and Multicentric Castleman Disease.

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