The 21^st century has provided new technical and educational opportunities as well as challenges which have not been approached and exploited sufficiently by traditional scientific journals. Furthermore, case reports are usually "neglected" by traditional journals for a variety of reasons, including limited space in the hardcopy version of the journal issue and priority over original research and review articles. The Journal of Radiology Case Reports is a new generation of journals, which is dedicated to provide open-access, high-quality, peer-reviewed and interactive Radiology case reports.