The Teaching Point

Primary bone malignancies such as undifferentiated pleomorphic sarcoma (UPS) are rare, but can occur in patients with osteopetrosis. Careful clinical and radiologic follow-up with standard skeletal surveys and advanced imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) are important since osseous lesions can be masked by underlying osteopetrosis on scintigraphic imaging.






Bookmark and Share

From the manuscript

Pleomorphic Sarcoma in a Patient with Osteopetrosis

Free full text article: Pleomorphic Sarcoma in a Patient with Osteopetrosis

Abstract
Osteopetrosis comprises a rare, heterogeneous group of heritable conditions that are characterized by a defect in bone resorption by osteoclasts. We report the case of a 53-year-old woman with previously undiagnosed osteopetrosis who presented with a pathologic proximal humeral fracture secondary to pleomorphic sarcoma, which is previously undescribed in the English literature. Management of the primary lesion necessitated ablative surgery, but the malignancy nonetheless was associated with rapidly progressive metastatic disease.






References



1. Rao VM, Dalinka MK, Mitchell DG, Spritzer CE, Kaplan F, August CS. Osteopetrosis: MR characteristics at 1.5 T. Radiology 1986;161(1):217-20
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


2. Del Fattore A, Cappariello A, Teti A. Genetics, pathogenesis and complications of osteopetrosis. Bone 2008;42(1):19-29
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


3. Askmyr MK, Fasth A, Richter J. Towards a better understanding and new therapeutics of osteopetrosis. Br J Haematol 2008;140(6):597-609
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


4. Smahi A, Courtois G, Rabia SH, Doffinger R, Bodemer C, Munnich A. The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes. Hum Mol Genet 2002;11(20):2371-5
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


5. Tolar J, Teitelbaum SL, Orchard PJ. Osteopetrosis. N Engl J Med 2004;351(27):2839-49
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


6. Yoshida H, Hayashi S, Kunisada T, Ogawa M, Nishikawa S, Okamura H. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 1990;345(6274):442-4
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


7. Li J, Geng ZJ, Lv XF, Zhang XK, Xie CM. Computed tomography and magnetic resonance imaging findings of malignant fibrous histiocytoma of the head and neck. Mol Clin Oncol 2016;4(5):888-92
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


8. Muler JH, Paulino AF, Roulston D, Baker LH. Myxoid malignant fibrous histiocytoma with multiple primary sites. Sarcoma 2002;6(1):51-5
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


9. Demiralp B, Erler K, Ozturan EK, Bek D, Ozdemir T, Kurt B. An uncommon presentation of malignant fibrous histiocytoma of the calcaneus. J Am Podiatr Med Assoc 2007;97(3):218-22
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


10. Enzinger FW, S. Soft Tissue Tumors. Soft Tissue Tumors Mosby Inc.; 1995, p
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


11. Lopez-Barea F, Rodriguez-Peralto JL, Burgos-Lizalde E, Gonzalez-Lopez J, Sanchez-Herrera S. Case report 639: Malignant fibrous histiocytoma (MFH) of the patella. Skeletal Radiol 1991;20(2):125-8
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


12. Papagelopoulos PJ, Mavrogenis AF, Galanis EC, Chloros GD, Papaparaskeva KT. Malignant fibrous histiocytoma of bone associated with type-1 neurofibromatosis. A case report J Bone Joint Surg Am 2005;87(2):399-403
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


13. Zlowodzki M, Allen B, Schreibman KL, Vance RB, Kregor PJ. CASE REPORTS: malignant fibrous histiocytoma of bone arising in chronic osteomyelitis. Clin Orthop Relat Res 2005;439:269-73
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


14. Lopes F. [Sarcomatous degeneration in a case of osteopetrosis]. J Belge Radiol 1952;35(1):212-5
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


15. Fadda GM, Santeufemia DA, Rocca PC, Costantino S, Sanna G, Sarobba MG. Small cell lung cancer in a young patient with osteopetrosis. Tumori 2006;92(6):563-6
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


16. Hendren SK, Wang J, Gorman J, Peacock T, Hershock DM, Rosato EF. Esophagectomy and splenectomy in a patient with osteopetrosis. J Thorac Cardiovasc Surg 2005;129(6):1457-8
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


17. Hashino S, Hirota G, Hasegawa M, Chiba K, Toyoshima N, Suzuki S. Peripheral T-cell lymphoma in a patient with osteopetrosis. Ann Hematol 2001;80(6):376-8
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


18. Prasad R, Jaiswal BP, Mishra OP, Singh UK. Association of possible osteopetrosis with acute myeloid leukaemia in a child. BMJ Case Rep 2013;2013
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


19. Toren A, Neumann Y, Meyer JJ, Mandel M, Schiby G, Kende G. Malignant osteopetrosis manifested as juvenile chronic myeloid leukemia. Pediatr Hematol Oncol 1993;10(2):187-9
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


20. Greene GS, Bonakdarpour A, Levy W. Case report 278. Osteopetrosis (tarsa type) with hemorrhagic cyst of the right sixth rib (proved) and the left second rib (presumptive) Skeletal Radiol 1984;12(1):59-62
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


21. Ferrari C, Niccoli Asabella A, Altini C, Rubini G. A rare case of osteopetrosis mimicking osteosarcoma: 18F-FDG PET/CT findings in an unexpected diagnosis. Nuklearmedizin 2016;55(1):N1-3
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


22. Weiss SW, Enzinger FM. Malignant fibrous histiocytoma: an analysis of 200 cases. Cancer 1978;41(6):2250-66
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


23. Demetri GD, Antonia S, Benjamin RS, Bui MM, Casper ES, Conrad EU, 3rd. Soft tissue sarcoma. J Natl Compr Canc Netw 2010;8(6):630-74
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


24. Berrington de Gonzalez A, Kutsenko A, Rajaraman P. Sarcoma risk after radiation exposure. Clin Sarcoma Res 2012;2(1):18
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


25. Mark RJ, Poen J, Tran LM, Fu YS, Selch MT, Parker RG. Postirradiation sarcomas. A single-institution study and review of the literature Cancer 1994;73(10):2653-62
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


26. Pitcher ME, Davidson TI, Fisher C, Thomas JM. Post irradiation sarcoma of soft tissue and bone. Eur J Surg Oncol 1994;20(1):53-6
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


27. Lehnhardt M, Daigeler A, Homann HH, Schwaiberger V, Goertz O, Kuhnen C. MFH revisited: outcome after surgical treatment of undifferentiated pleomorphic or not otherwise specified (NOS) sarcomas of the extremities -- an analysis of 140 patients. Langenbecks Arch Surg 2009;394(2):313-20
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


28. Hornick JL. Subclassification of pleomorphic sarcomas: How and why should we care? Ann Diagn Pathol 2018;37:118-24.
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


29. Jones NB, Iwenofu H, Scharschmidt T, Kraybill W. Prognostic factors and staging for soft tissue sarcomas: an update. Surg Oncol Clin N Am 2012;21(2):187-200
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


30. Gronchi A, Lo Vullo S, Colombo C, Collini P, Stacchiotti S, Mariani L. Extremity soft tissue sarcoma in a series of patients treated at a single institution: local control directly impacts survival. Ann Surg 2010;251(3):506-11
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


31. Eilber FC, Rosen G, Nelson SD, Selch M, Dorey F, Eckardt J. High-grade extremity soft tissue sarcomas: factors predictive of local recurrence and its effect on morbidity and mortality. Ann Surg 2003;237(2):218-26
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


32. Kamat NV, Million L, Yao DH, Donaldson SS, Mohler DG, van de Rijn M. The Outcome of Patients With Localized Undifferentiated Pleomorphic Sarcoma of the Lower Extremity Treated at Stanford University. Am J Clin Oncol 2019;42(2):166-71
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


33. Lewis JJ, Leung D, Heslin M, Woodruff JM, Brennan MF. Association of local recurrence with subsequent survival in extremity soft tissue sarcoma. J Clin Oncol 1997;15(2):646-52
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


34. Vodanovich DA, Spelman T, May D, Slavin J, Choong PFM. Predicting the prognosis of undifferentiated pleomorphic soft tissue sarcoma: a 20-year experience of 266 cases. ANZ J Surg 2019;89(9):1045-50
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


35. Winchester D, Lehman J, Tello T, Chimato N, Hocker T, Kim S. Undifferentiated pleomorphic sarcoma: Factors predictive of adverse outcomes. J Am Acad Dermatol 2018;79(5):853-9
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


36. Pobirci D, Bogdan F, Pobirici O, Petcu C, Rosca E. Study of malignant fibrous histiocytoma Clinical, statistic and histopatological interrelation. Romanian Journal of Morphology and Embryology 2011;52:385-8
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


37. Ozkurt B, Basarir K, Yildiz YH, Kalem M, Saglik Y. Primary malignant fibrous histiocytoma of long bones: long-term follow-up. Eklem Hastalik Cerrahisi 2016;27(2):94-9
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine




Search for articles with similar topics:

Keyword search:

1. bone scintigraphy

2. humerus

3. malignant fibrous histiocytoma

4. osteopetrosis

5. undifferentiated pleomorphic sarcoma of bone


This article belongs to the MSK section.


Search for more in the Internet

Peer-reviewed Radiology Search




Discuss it!

Bookmark and Share




© Journal of Radiology Case Reports - The Interactive Radiology Journal
Affiliated journal of Radiolopolis - The International Radiology Community


The Journal of Radiology Case Reports