The Teaching Point

IgG4-related disease is characterized by elevated serum IgG4 and mass like tissue infiltration by IgG4-positive plasma cells and is associated with a myriad of autoimmune conditions. Imaging findings are nonspecific and in many cases may mimic malignancy, necessitating tissue sampling to confirm the diagnosis as patients with IgG4-related disease respond well to corticosteroids and can be managed expectantly.






Bookmark and Share

From the manuscript

IgG4-Related Disease Presenting as a Solitary Neck Mass

Free full text article: IgG4-Related Disease  Presenting as a Solitary Neck Mass

Abstract
IgG4-related disease is a newly recognized entity associated with autoimmune conditions involving almost every organ system. It is characterized by elevated serum IgG4 as well as mass like tissue infiltration by IgG4-positive plasma cells. Imaging findings are nonspecific, vary depending on the site of disease, and include mass like enlargement of the salivary or lacrimal glands and enlarged lymph nodes. Radiographic findings often mimic malignancy, necessitating tissue sampling to confirm the diagnosis. Distinguishing IgG4-related disease from malignancy is important as IgG4 responds well to steroids and conservative management.






References



1. Kamisawa T, Okamoto A. Autoimmune pancreatitis: proposal of IgG4-related sclerosing disease. J Gastroenterol 2006 Jul; 41(7):613-625
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


2. Deshpande V, Zen Y, Chan J. Consensus statement on the pathology of IgG4-related disease. Mod Pathol 2012 Sep; 25:1181-1192
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


3. Masaki Y, Kurose N, Umehara H. IgG4 related disease: a novel lymphoproliferative disorder discovered and established in Japan in the 21st century. J Clin Exp Hematop 2011; 51:13-20
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


4. Kawaguchi K, Koike M, Tsuruta K, Okamoto A, Tabata I, Fujita N. Lymphoplasmacytic sclerosing pancreatitis with cholangitis: a variant of primary sclerosing cholangitis extensively involving pancreas. Hum Pathol 1991;22:387-395
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


5. Hirano K, Shiratori Y, Komatsu Y. Involvement of the biliary system in autoimmune pancreatitis: a follow-up study. Clin Gastroenterol Hepatol 2003;1:453-564
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


6. Hamano H, Kawa S, Ochi Y. Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis. Lancet 2002;359:1403-1404
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


7. Uchida K, Okazaki K, Asada M. Case of chronic pancreatitis involving an autoimmune mechanism that extended to retroperitoneal fibrosis. Pancreas 2003;26:92-94
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


8. Fukukura Y, Fujiyoshi F, Nakamura F, Hamada H, Nakajo M. Autoimmune pancreatitis associated with idiopathic retroperitoneal fibrosis. AJR Am J Roentgenol 2003;181:993-995
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


9. Yamamoto M, Takahashi H, Sugai S, Imai K. Clinical and pathological characteristics of Mikulicz`s disease (IgG4-related plasmacytic exocrinopathy). Autoimmun Rev 2005;4:195-200
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


10. Shimizu I, Nasu K, Sato K, Ueki H. Lymphadenopathy of IgG4-related sclerosing disease: three case reports and review of literature. Int J Hematol 2010; 92:751-756
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


11. Cheuk W, Yuen H, Chu S, Chiu E, Lam L, Chan J. Lymphadenopathy of IgG4-related sclerosing disease. Am J Surg Pathol 2008 May; 32(5):671-681
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


12. Cheuk W, Tam F, Chan A, Luk I. Idiopathic Cervical Fibrosis - A new member of IgG4-related sclerosing diseases: Report of 4 cases, 1 complicated by composite lymphoma. Am J Surg Pathol 2010 Nov; 34(11):1678-1685
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


13. Leporati P, Landek-Salgado M, Lupi I, Chiovato L, Caturegli P. IgG4-related hypophysitis: A new addition to the hypophysitis spectrum. J Clin Endocrinol Metab 2011 Jul; 96(7):1971-1980
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


14. Wong S, Lam W, Wong W, Lee K. Hypophysitis presented as inflammatory pseudotumor in immunoglobulin G4-related systemic disease. Hum Pathol 2007 Nov; 38(11):1720-1723
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


15. van der Vliet H, Perenboom R. Multiple pseudotumors in IgG4-associated multifocal systemic fibrosis. Ann Intern Med 2004 Dec; 141(11):896-897
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


16. Takeda S, Haratake J, Kasai T, Takaeda C, Takazakura E. IgG4-associated idiopathic tubulointerstitial nephritis complicating autoimmune pancreatitis. Nephrol Dial Transplant 2004; 19(2):474-476
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


17. Uchiyama-Tanaka Y, Mori Y, Kimura T. Acute tubulointerstitial nephritis associated with autoimmune-related pancreatitis. Am J Kidney Dis 2004 March; 43(3):e18-25
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


18. Taniguchi T, Ko M, Seko S. Interstitial pneumonia associated with autoimmune pancreatitis. Gut 2004 May; 53(5):770-771
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


19. Komatsu K, Hamano H, Ochi Y. High prevalence of hypothyroidism in patients with autoimmune pancreatitis. Dig Dis Sci 2005 Jun; 50(6):1052-1057
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


20. Kamisawa T, Okamoto A. IgG4-related sclerosing disease. World J Gastroenterol 2008 Jul; 14(25):3948-2955
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


21. Cheuk W, Chan J. IgG4-related sclerosing disease: A critical appraisal of an evolving clinicopathologic entity. Adv Anat Pathol 2010 Sept; 17(5):303-332
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


22. Okazaki K, Uchida K, Ohana M. Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response. Gastroenterology 2000 March; 118(3):573-581
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


23. Zen Y, Nakanuma Y. IgG4-related disease: A cross-sectional study of 114 cases. Am J Surg Pathol 2010 Dec; 34(12):1812-1819
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


24. Vlachou P, Khalili K, Jang H, Fischer S, Hirschfield G, Kim T. IgG4-related sclerosing disease: autoimmune pancreatitis and extrapancreatic manifestations. Radiographics 2011 Sept; 31(5):1379-1402
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


25. Toyoda K, Oba H, Kutomi K. MR imaging of IgG4-related disease in the head and neck and brain. Am J Neuroradiol 2012 June; 33(11):2136-9
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


26. Fujita A, Sakai O, Chapman M, Sugimoto H. IgG4-related Disease of the Head and Neck: CT and MR Imaging Manifestations. Radiographics 2012; 32:1945-1958
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


27. Fujinaga Y, Kadoya M, Kawa S. Characteristic findings in images of extra-pancreatic lesions associated with autoimmune pancreatitis. Eur J Radiol 2010 Nov; 76(2):228-238
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


28. Horger M, Lamprecht HG, Bares R. Systemic IgG4-related sclerosing disease: spectrum of imaging findings and differential diagnosis. Am J Roentgenol 2012 Sep; 199(3):W276-282
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


29. Rice DH, Batsakis JG, Coulthard SW. Sclerosing cervicitis: homologue of sclerosing retroperitonitis and mediastinitis. Arch Surg 1975 Jan; 110(1):120-122
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


30. Koeller K, Alamo L, Adair F, Smirniotopoulos J. Congenital cystic masses of the neck: radiologic-pathologic correlation. Radiographics 1999 Jan-Feb; 19(1): 121-46
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


31. Ahuja A, King A, Metreweli C. Second branchial cleft cysts: variability of sonographic appearances in adult cases. AJNR Am J Neuroradiol 2000 Feb;21(2):315-9
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


32. King A, Lei K, Ahuja A. MRI of neck nodes in non-Hodgkin`s lymphoma of the head and neck. Br J Radiol 2004 Feb; 77 (914), 111-5
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


33. Aiken A, Glastonbury C. Imaging Hodgkin and Non-Hodgkin Lymphoma in the Head and Neck. Radiol Clin North Am 2008 Mar; 46(2), 363-78
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


34. Van den Brekel M, Stel H, Castelijns J, Nauta J, van der Waal I, Valk J, Meyer C, Snow G. Cervical lymph node metastasis: assessment of radiologic criteria. Radiology 1990 Nov; 177(2):379-84
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


35. Sumi M, Sakihama N, Sumi T, Morikawa M, Uetanic M, Kabasawa H, Shigeno K, Hayashi K, Takahashi H, Nakamura T. Discrimination of metastatic cervical lymph nodes with diffusion-weighted MR imaging in patients with head and neck cancer. AJNR Am J Neuroradiol 2003 Sep; 24(8): 1627-34
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


36. Curtin H, Ishwaran H, Mancuso A, Dalley R, Caudry D, McNeil B. Comparison of CT and MR imaging in staging of neck metastasis. Radiology 1998 Apr; 207(1): 123-130
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


37. Sumi M, Ohki M, Nakamura T. Comparison of sonography and CT for differentiating benign from malignant cervical lymph nodes in patients with head and neck squamous cell carcinomas. AJR Am J Roentgenol 2001 Apr; 176(4):1019-24
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


38. Chikui T, Yonetsu K, Nakamura T. Multivariate feature analysis of sonographic findings of metastatic cervical lymph nodes: contribution of blood flow features revealed by power Doppler sonography for predicting metastasis. AJNR Am J Neuroradiol 2000 Mar; 21(3):561-7
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


39. Stone J, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med 2012 Feb; 366:539-551
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine




Search for articles with similar topics:

Keyword search:

1. IgG4 related disease

2. neck mass

3. sclerosing disease

4. autoimmune


This article belongs to the Neuro section.


Search for more in the Internet

Peer-reviewed Radiology Search




Discuss it!

Bookmark and Share




© Journal of Radiology Case Reports - The Interactive Radiology Journal
Affiliated journal of Radiolopolis - The International Radiology Community


The Journal of Radiology Case Reports