Question:

What is the most common explanation for proptosis on clinical examination?
1. Orbital plasmablastic lymphoma.
2. Cavernous sinus thrombosis.
3. Orbital cellulitis.
4. Grave`s disease.
5. Spheno-orbital meningioma





Answer:

The correct answer for the question "What is the most common explanation for proptosis on clinical examination?" is:

4. Grave`s disease.



Explanation
While all of these answer choices are possible explanations for the appearance of proptosis and are suspected disorders for which clinicians order orbital imaging studies, Grave`s disease is the most common etiology of proptosis in the general population.  Orbital plasmablastic lymphoma is an extremely rare condition with very few reported cases [page 3, line 7].



From the manuscript:
Orbital plasmablastic lymphoma with remission following chemotherapy
Radiology Case. 2011 Feb; 5(2):1-7


This article belongs to the Neuro section.




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From the manuscript

Orbital plasmablastic lymphoma with remission following chemotherapy

Free full text article: Orbital plasmablastic lymphoma with remission following chemotherapy

Abstract
We report the case of a middle-aged HIV-positive man who presented with proptosis and retro-ocular pain. On CT and MR imaging, a retro-orbital enhancing mass was seen, and PET/CT revealed this lesion as well as a similarly characterized mass in the nasopharynx to be hypermetabolic. Biopsy and subsequent pathological characterization revealed this mass to be plasmablastic lymphoma (PBL), a rare form of non-Hodgkin`s lymphoma associated with HIV-infection. PBL is a diffuse B-cell lymphoma with characteristic cell marker patterns. The most common site of this malignancy is within the oral cavity. This case constitutes an unusual orbital manifestation of plasmablastic lymphoma as well as an unusual case in its response to chemotherapy. This case illustrates the importance of functional imaging with PET/CT in the diagnosis, management, and follow-up of plasmablastic lymphoma.






References



1. Raviele PR, Pruneri G, Maiorano E. Plasmablastic lymphoma: a review. Oral Dis 2009;15(1):38-45.
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2. Porter SR, Diz Dios P, Kumar N, Stock C, Barrett AW, Scully C. Oral plasmablastic lymphoma in previously undiagnosed HIV disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87(6):730-734.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


3. Folk G, Abbondanzo S, Foss R, Childers E. Clinicopathologic features of oral plasmablastic lymphoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;98(2):204.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


4. Scheper MA, Nikitakis NG, Fernandes R, Gocke CD, Ord RA, Sauk JJ. Oral plasmablastic lymphoma in an HIV-negative patient: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100(2):198-206.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


5. Tavora F, Gonzalez-Cuyar LF, Sun CJ, Burke A, Zhao XF. Extra-oral plasmablastic lymphoma: report of a case and review of literature. Human Pathology 2006;37:1233-1236.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


6. Flaitz CM, Nichols CM, Walling DM, Hicks MJ. Plasmablastic lymphoma: an HIV-associated entity with primary oral manifestations. Oral Oncol 2002;38(1):96-102.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


7. Ninet VZ, Casimiro LM, De Miguel VA, Corell JJV. Cutaneous plasmablastic lymphoma in an HIV-positive female. Journal of the American Academy of Dermatology 2008;58(2):AB101.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


8. Barkhuysen R, Merkx MAW, Weijs WLJ, Gerlach NL, Bergé SJ. Plasmablastic lymphoma mimicking orbital cellulitis. Oral Maxillofac Surg 2008;12(3):125-128.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


9. Morley AMS, Verity DH, Meligonis G, Rose GE. Orbital Plasmablastic Lymphoma-Comparison of a Newly Reported Entity with Diffuse Large B-cell Lymphoma of the Orbit. Orbit 2009;28(6):425-429.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


10. Nasta SD, Carrum GM, Shahab I, Hanania NA, Udden MM. Regression of a plasmablastic lymphoma in a patient with HIV on highly active antiretroviral therapy. Leuk Lymphoma 2002;43(2):423-426.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


11. Sharma R, Abdou S, Plymyer MR, Rohatgi C. Disseminated Plasmablastic Lymphoma. Journal of American College of Surgeons 2004;199(4):654-655.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


12. Spina M, Gloghini A, Tirelli U, Carbone A. Therapeutic options for HIV-associated lymphomas. Expert Opinion on Pharmacotherapy 2010;11(15):2471-2481.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


13. Khan MA, Jakate S, Komanduri S. Rare AIDS-associated plasmablastic lymphoma as the initial presentation of AIDS. Clin Adv Hematol Oncol 2010 Jan;8(1):55-7.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


14. Armstrong R, Bradrick J, Liu YC. Spontaneous regression of an HIV-associated plasmablastic lymphoma in the oral cavity: a case report. J Oral Maxillofac Surg 2007;65(7):1361-1364.
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