Question:

Which of the following about Systemic Mastocytosis is True?
1. The condition is most commonly seen in children.
2. Patients commonly report a family history of atopy.
3. Males are more commonly affected than females.
4. The greatest risk factor is advanced age.
5. Urticaria Pigmentosa is the most common presentation in adults.





Answer:

The correct answer for the question "Which of the following about Systemic Mastocytosis is True?" is:

1. The condition is most commonly seen in children.



Explanation
1. The condition is most commonly seen in children. [Seventy five percent of cases are diagnosed in children as Urticaria Pigmentosa (UP) with a peak incidence of 2 years]
2. Family history is not a risk factor for developing the condition. There are no known risk factors. [Pathogenesis appears to result from abnormal mast cell proliferation due to a random mutation in the kit gene]
3. Males and females are equally affected by the condition [There is no gender predilection]
4. Age is not a risk factor [There are no known risk factors]
5. UP is the most common form in children, not adults. [The most commonly encountered form in adults is the Indolent Type (Indolent System Mastocytosis) with a median age of 49 years at diagnosis]



From the manuscript:
Systemic Mastocytosis: A Rare Cause of Single Vertebral Body Uptake on Bone Scan
Radiology Case. 2015 Feb; 9(2):31-41


This article belongs to the Nucs section.




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From the manuscript

Systemic Mastocytosis: A Rare Cause of Single Vertebral Body Uptake on Bone Scan

Free full text article: Systemic Mastocytosis: A Rare Cause of Single Vertebral Body Uptake on Bone Scan

Abstract
Systemic Mastocytosis is a rare condition characterized by the abnormal proliferation of Mast Cells. Presentation as a solitary vertebral body lesion is extremely uncommon and may be confused with more ominous conditions such as metastasis. Familiarity with the condition can heighten clinical suspicion, direct tissue diagnosis, guide management and indicate appropriate follow up. We present a case of a 64-year-old woman undergoing staging for recently diagnosed breast cancer who was found to have Systemic Mastocytosis of a single vertebral body.






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